1 case of mouse hypothalamus injected with human ACP cystic fluid,1 case of mouse hypothalamus injected with PBS,1 case of human ACP tumor tissue were used for scRNA-seq Raw sequence reads. Mouse & Human

The mechanism by which adamantinomatous craniopharyngioma (ACP) damages the hypothalamus is still unclear. Cyst fuid rich in lipids and infammatory factors is a characteristic pathological manifestation of ACP and may play a very important role in hypothalamic injury caused by tumors.

造釉细胞瘤型颅咽管瘤（adamantinomatous craniopharyngioma, ACP）损伤下丘脑的具体机制目前仍不明确。富含脂质与炎症因子的囊液是该肿瘤的特征性病理表现，且可能在肿瘤引发的下丘脑损伤中发挥极为关键的作用。