Repurposing of antivirals is an attractive therapeutic option for the treatment of COVID-19. Main protease (Mpro), also called 3 C-like protease (3CLpro) is a key protease of SARS-CoV-2 involved in vi

NIAID Data Ecosystem50

Table_1_Common Nodes of Virus–Host Interaction Revealed Through an Integrated Network Analysis.XLS

病毒-宿主相互作用

抗病毒药物重定位

Viruses are one of the major causes of acute and chronic infectious diseases and thus a major contributor to the global burden of disease. Several studies have shown how viruses have evolved to hijack

NIAID Data Ecosystem30

Kazakiewicz et al., 2015

抗病毒药物重定位

支原体感染

Supplementary files for Kazakiewicz D, Karr JR, Langner KM & Plewczynski D. Combined systems and structural modeling repositions antibiotics for Mycoplasma genitalium. (In submission).

Figshare2016-01-19 更新60

Niclosamide as a chemical probe for analyzing SARS-CoV-2 modulation of host cell lipid metabolism. Niclosamide as a chemical probe for analyzing SARS-CoV-2 modulation of host cell lipid metabolism

宿主-病毒互作

抗病毒药物重定位

Purpose: The global effort to combat COVID-19 rapidly produced a shortlist of approved drugs with anti-viral activities for clinical repurposing. However, the jump to clinical testing was lethal in so

NIAID Data Ecosystem40

COVID_CDR Pairwise similarity and network separation score

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