Structural Biology of Macromolecules and Macromolecular complexes from India

Structural biology research groups located in India constitute the INDIA-BAG and will utilize MX, SAXS and CryoEM to study different biological macromolecules. Together, these groups address multiple pathways in animals, plants, bacteria and fungi. These studies will provide fundamental mechanistic insight regarding different processes critical for the survival and propagation of the relevant organism. Many groups in the BAG study proteins from pathogens to identify novel intervention points that can be the targeted with small molecule inhibitors to inhibit the growth of the corresponding infectious agents. There are more than 50 groups that are part of this BAG and the allocated beamtime will be available for over 500 young researchers. A brief description of all the research groups is provided in the global summary and a summary of the research contributions involving data collected at ESRF is provided in the last BAG report.

位于印度的结构生物学研究团队组成了INDIA-BAG，将借助MX（大分子X射线晶体学，Macromolecular X-ray Crystallography）、SAXS（小角X射线散射，Small Angle X-ray Scattering）与CryoEM（冷冻电镜，Cryo-Electron Microscopy）技术开展各类生物大分子的研究工作。这些团队将共同聚焦动物、植物、细菌与真菌中的多条信号通路，此类研究将为相关生物体存活与增殖所需的关键生命过程提供基础性的机制解析。该协作组内多个团队针对病原体来源蛋白质展开研究，以识别全新的干预靶点，可通过小分子抑制剂靶向作用，抑制相应感染性病原体的增殖。本次协作组共包含50余个研究团队，分配的光束线机时将面向500余名青年研究者开放。所有研究团队的简要介绍可参见全局综述，而涉及ESRF（欧洲同步辐射光源，European Synchrotron Radiation Facility）采集数据的研究成果总结则收录于最新一期BAG报告中。