DNA methylome comparison of low IQ versus high IQ trisomy 21. DNA methylome comparison of low IQ versus high IQ trisomy 21

Methylomic profiling in trisomy 21 for identification of cognition- and Alzheimer’s disease-related dysregulation. Overall design: Bisulphite converted DNA from 32 individuals were hybridised to the Illumina Infinium MethylationEPIC BeadChip (11 T21 samples, 8 IQ+ and 3 IQ-, and 21 healthy controls with high IQs)

用于识别认知功能与阿尔茨海默病相关失调的21三体综合征甲基化组分析。总体实验设计：将32名个体的亚硫酸氢盐转化DNA与Illumina Infinium甲基化EPIC芯片（Illumina Infinium MethylationEPIC BeadChip）进行杂交；样本包含11例21三体（T21）样本（其中8例为高智商亚组、3例为低智商亚组），以及21例高智商健康对照个体。