The identity and association of top 20 miRNA-target-site SNPs with documented SNP markers in the YRI population.

Ps: the Affymatrix exon array transcript probe set; SNP1: the SNP marker documented in [13]; SNP2: the SNP located in a predicted miRNA target site in the 3′ UTR region of the corresponding gene; LD: the linkage disequilibrium value between SNP1 and SNP2; TSE: the miRNA target site effect; Adj.p: the FDR corrected p-value for TSE; miRNA: the MiRBase ID(s) of a human miRNA with the SNP2 in the predicted target site. The common prefix “hsa-mir-” in the IDs is omitted. In rows with bold fonts, the SNP2 is same as the SNP1. See the method section for the calculations of LD and TSE. The modules are first ranked and selected by the significance level indicated by adj.p, and then presented by the alphabetic order of the gene names.

注：Affymatrix外显子阵列转录本探针集（Affymatrix exon array transcript probe set）；SNP1：文献[13]中记载的单核苷酸多态性（Single Nucleotide Polymorphism, SNP）标记；SNP2：位于对应基因3′非翻译区（3′ UTR）预测微小RNA（microRNA, miRNA）靶位点内的单核苷酸多态性标记；LD：SNP1与SNP2之间的连锁不平衡（linkage disequilibrium）值；TSE：微小RNA靶位点效应（miRNA target site effect）；Adj.p：针对TSE经错误发现率（False Discovery Rate, FDR）校正后的P值；miRNA：包含SNP2的人类微小RNA的MiRBase数据库编号，该类编号的通用前缀"hsa-mir-"已被省略。在加粗字体的行中，SNP2与SNP1完全一致。有关LD与TSE的计算方法详见方法部分。模块首先依据adj.p所指示的显著性水平进行排序与筛选，随后按照基因名称的字母顺序进行展示。