A New Strategy for Efficient Synthesis of Medium and Large Ring Lactones without High Dilution or Slow Addition

We have developed an efficient method for medium and large ring lactone synthesis by a conceptually different ring-expansion strategy. The design of an unprecedented ring conjunction mode of oxetene, combined with the appropriate choice of a Lewis acid promoter and an additive, constitutes the key components of the new process. Enabled by this new approach, the reaction does not require high dilution or slow addition.

我们开发了一种基于概念迥异的环扩张策略，用于中环及大环内酯类化合物合成的高效方法。氧杂环丁烯（oxetene）前所未有的环结合模式设计，结合路易斯酸促进剂与添加剂的合理选择，构成了该新工艺的核心要素。依托这一新方法，该反应无需高稀释条件或慢速滴加操作。