DNA damage response-related parameters and associated Wilcoxon rank-sum tests in platinum-sensitive (A2780) and platinum-resistant (A2780/C30) cell lines.

1cells that are defined as having more than 5 foci per cell, expressed as a fraction of 100
2Olive Tail Moment (OTM) values, arbitrary units
3AUC values, expressed as (% of γH2AX positive staining cells) x (carboplatin dose)
4AUC values (expressed as OTM x carboplatin dose)
5t1/2 for γH2AX foci removal, in h
6t1/2 values for carboplatin-induced damage repair, in h
7apoptosis rates expressed as doses of carboplatin inducing apoptosis (as defined in the Materials and Methods section)
8AUC values, expressed as (% of pan-nuclear staining cells) x (carboplatin dose)
9Wilcoxon rank-sum tests.
DNA damage response-related parameters and associated Wilcoxon rank-sum tests in platinum-sensitive (A2780) and platinum-resistant (A2780/C30) cell lines.

1. 每细胞内焦点数超过5个的细胞占比，以百分比形式呈现
2. 橄榄尾矩（Olive Tail Moment, OTM）数值，单位为任意单位
3. 曲线下面积（AUC）数值，以「γH2AX阳性染色细胞百分比 × 卡铂剂量」的形式计算表达
4. 曲线下面积（AUC）数值，以「OTM × 卡铂剂量」的形式计算表达
5. γH2AX焦点清除的半衰期（t1/2），单位为小时（h）
6. 卡铂诱导的DNA损伤修复半衰期（t1/2），单位为小时（h）
7. 凋亡率以诱导细胞凋亡的卡铂剂量进行表征，具体定义详见材料与方法章节
8. 曲线下面积（AUC）数值，以「全核染色细胞百分比 × 卡铂剂量」的形式计算表达
9. Wilcoxon秩和检验（Wilcoxon rank-sum test）
铂敏感型（A2780）与铂耐药型（A2780/C30）细胞系的DNA损伤应答相关参数及对应Wilcoxon秩和检验