THE IMPORTANCE AND SIGNIFICANCE OF DEVELOPING ANTHELMINTIC SUPPOSITORIES FOR CHILDREN IN UZBEKISTAN

Helminthiases are among the most widespread parasitic diseases affecting children worldwide and represent a significant public health concern, particularly in developing countries. According to the World Health Organization, hundreds of millions of school-aged children are infected with intestinal helminths globally [1]. In Uzbekistan, ascariasis, enterobiasis, and other helminth infections remain prevalent and continue to negatively affect children’s health. Most currently available anthelmintic medicines are administered orally, which poses challenges in pediatric practice due to poor compliance and gastrointestinal adverse effects. This article substantiates the scientific, clinical, and social importance of developing pediatric anthelmintic suppositories (rectal dosage forms) in Uzbekistan.蠕虫病（Helminthiases）是全球范围内影响儿童的最广泛的寄生虫病之一，亦是一项重大公共卫生问题，在发展中国家尤为突出。据世界卫生组织（World Health Organization）统计，全球范围内有数以亿计的学龄儿童感染肠道蠕虫[1]。在乌兹别克斯坦，蛔虫病（ascariasis）、蛲虫病（enterobiasis）及其他蠕虫感染仍呈流行态势，并持续对儿童健康造成不良影响。目前多数可用的抗蠕虫药物（anthelmintic medicines）均采用口服给药方式，由于患儿依从性较差且易引发胃肠道不良反应，该给药方式在儿科临床实践中面临诸多挑战。本文论证了在乌兹别克斯坦研发儿科抗蠕虫栓剂（直肠给药剂型）的科学、临床及社会价值。