Thrombospondin-4 is a soluble dermal inflammatory signal that activates the fibroblast migration for skin regeneration and wound healing

The present study aimed to investigate the role of Thbs4 in skin regeneration and elucidate its effects on cellular responses. Here we show that Thbs4 expression is upregulated in healing skin wounds and wound healing can be promoted by the application of recombinant Thbs4 protein. Thbs4 was shown to promote keratinocyte proliferation and fibroblast migration by activating β-catenin signalling cascade. This indicates that incorporating Thbs4 into novel wound healing therapies can be a promising therapeutic strategy for hard-to-heal chronic wounds. Changes in human primary skin fibroblast mRNA profiles in response to stimulation with recombinant Thbs4 protein

本研究旨在探究血小板反应蛋白4（Thbs4）在皮肤再生中的作用，并阐明其对细胞应答的调控效应。本研究发现，在愈合中的皮肤伤口内Thbs4的表达水平上调，且外源性施加重组Thbs4蛋白可促进伤口愈合。研究证实，Thbs4可通过激活β-连环蛋白（β-catenin）信号级联通路，促进角质形成细胞增殖与成纤维细胞迁移。上述结果表明，将Thbs4纳入新型伤口愈合治疗方案，可为难愈性慢性伤口提供极具潜力的治疗策略。本数据集包含重组Thbs4蛋白刺激下人原代皮肤成纤维细胞的mRNA表达谱变化。