Rh(III)-Catalyzed Cascade Oxidative Olefination/Cyclization of Picolinamides and Alkenes via C–H Activation

Rh­(III)-catalyzed cascade oxidative alkenylation/cyclization of picolinamides and alkenes to furnish pyrido pyrrolone derivatives is described, in which three C–H bonds and one N–H bond broke, while one C–C bond and one C–N bond formed. The reaction proceeded with high yield and high regioselectivity and stereoselectivity. Moreover, copper acetate can also be used in catalytic amounts with O2 serving as the terminal oxidant.

本研究报道了铑(III)(Rh(III))催化的吡啶甲酰胺(picolinamides)与烯烃(alkenes)的串联氧化烯烃化/环化反应，用以合成吡啶并吡咯酮衍生物(pyrido pyrrolone derivatives)。该反应过程中断裂了三根碳氢键(C–H bonds)与一根氮氢键(N–H bond)，同时生成一根碳碳键(C–C bond)与一根碳氮键(C–N bond)。该反应具备优异的收率、区域选择性与立体选择性。此外，乙酸铜(copper acetate)可作为催化量试剂，且以氧气(O2)作为终端氧化剂(terminal oxidant)。