Genome-wide analysis of long noncoding RNA expression profile in gastric cancer

Gastric cancer (GC) remains one of the most prevalent tumor worldwide, and ranks third in cancer-related deaths globally. Long non-coding RNAs (lncRNAs) have been reported to play significant role in the progression and metastasis in gastric cancer (GC), however, the molecular mechanism are largely elusive. We aim to identify up-regulated lncRNA in GC and study their function in promoting tumor progression and metastasis. Microarray expression profiling of mRNAs and lncRNAs were conducted using RNA extracted from six gastric cancer samples and matched adjacent normal tissues.

胃癌（Gastric Cancer, GC）仍是全球范围内最常见的恶性肿瘤之一，在全球癌症相关死亡原因中位列第三。长链非编码RNA（Long non-coding RNAs, lncRNAs）已被报道在胃癌进展与转移过程中发挥重要作用，但其相关分子机制在很大程度上仍尚不明确。本研究旨在筛选胃癌组织中上调表达的长链非编码RNA，并探究其在促进肿瘤进展与转移中的生物学功能。本研究采用从6例胃癌组织及其配对癌旁正常组织中提取的RNA，对信使RNA（Messenger RNA, mRNA）与长链非编码RNA进行了基因芯片表达谱分析。