Effect of mitochondrial sulfide on C. elegans transcriptome across the lifecourse

Living longer without simultaneously extending years spent in good health ('healthspan') is an increasing societal burden, demanding new therapeutic discovery. Hydrogen Sulfide (H2S) can correct disease-related mitochondrial metabolic deficiencies, and supraphysiological H2S concentrations can prolong healthspan. However, the efficacy, and mechanisms of mitochondria-targeted sulfide delivery molecules (mtH2S) administered across the adult lifecourse is unknown. Transcriptomics was thus employed to examine molecular responses of C. elegans to mitochondrial sulfide across different ages of the lifecourse.

寿命延长却未能同步提升健康寿命（healthspan）的情况正日益加重社会负担，亟需全新的治疗性研究突破。硫化氢（Hydrogen Sulfide，H₂S）可纠正疾病相关的线粒体代谢缺陷，而超生理浓度的硫化氢能够延长健康寿命。然而，针对在整个成年生命周期内给药的靶向线粒体硫化氢递送分子（mtH2S），其疗效与作用机制仍不明确。为此，本研究采用转录组学（Transcriptomics）技术，探究秀丽隐杆线虫（C. elegans）在生命周期不同年龄阶段对线粒体硫化氢递送的分子应答。