Dataset for meta-analysis and metaregression of published outcomes data on definitive radiotherapy with or without chemotherapy for locally advanced cervical cancer in patients with contraindications to cisplatin

We performed a systematic review and meta-analysis to examine the treatment outcomes in patients with locally advanced cervical cancer with contraindications to cisplatin, that were managed with definitive radiotherapy with or without chemotherapy. We then performed a metaregression to examine the effects of clinical and treatment variables on outcomes. We identified eligible studies and extracted relevant data using a standardized data extraction template. Table 1 summarizes the characteristics of the population or subgroup (including the nature of contraindication to cisplatin) and the intervention groups (radiotherapy, brachytherapy, and/or chemotherapy regimens) per each eligible study. Table 2 summarizes our assessment of the risk of bias for each study using templates that were based on the CASP Critical Appraisal Checklists. Tables 3 and 4 summarize the outcomes (tumor response, survival, compliance rates, and toxicity) for each intervention group. Table 5 consolidates numerical data from Tables 1, 3, and 4, suitable for meta-analyses and meta-regression. Table 6 is a composite database that contains the main template used in the preparation of the other datasets for the proportional meta-analyses and metaregression, given the variables and outcomes of interest. Table 7 is a composite database that contains the datasets used for the comparative meta-analyses. Figures 1 to 5b are Forests plots for pooled outcomes according to the intervention categories. Figures 6a to 6f are Forest plots for pooled outcomes according to the use or non-use of chemotherapy and nodal boost.

本研究针对存在顺铂（cisplatin）禁忌证的局部晚期宫颈癌患者，开展系统评价与Meta分析（meta-analysis），以考察其接受根治性放疗（definitive radiotherapy）联合或不联合化疗的治疗结局。随后开展Meta回归（metaregression）分析，探究临床与治疗变量对研究结局的影响。本研究通过标准化数据提取模板，筛选符合纳入标准的相关研究并提取有效数据。表1总结了每项符合纳入标准研究的研究人群或亚组特征（含顺铂禁忌证的具体类型）以及干预组方案（放疗、近距离放疗（brachytherapy）和/或化疗方案）；表2基于CASP关键评价清单（CASP Critical Appraisal Checklists）模板，对每项研究的偏倚风险进行评估并汇总结果；表3与表4汇总了各干预组的结局指标，包括肿瘤应答、生存情况、依从率及毒性反应；表5整合了表1、表3与表4中的数值型数据，适用于Meta分析及Meta回归分析；表6为复合数据库，收录了基于所关注的变量与结局指标，用于制备比例Meta分析及Meta回归分析所需其他数据集的核心模板；表7为复合数据库，收录了用于比较性Meta分析的数据集。图1至图5b为按干预类别划分的合并结局森林图（forest plot）；图6a至图6f为按是否联合化疗及是否行淋巴结推量照射（nodal boost）划分的合并结局森林图。