Predicting gait adaptations due to plantarflexor muscle weakness and contracture

Using an optimization framework (SCONE) and a musculoskeletal modeling package (OpenSim), we generated realistic simulations of walking at many speeds. We then modeled muscle weakness or contracture in the ankle plantarflexor muscles to study how these deficits contribute to observed gait changes.This project provides results from all of our simulations. We also provide Docker build instructions and SCONE setup files for others to reproduce our results. <br/><br/>This project includes the following software/data packages: <br/> <ul> <li> <a href="https://simtk.org/frs?group_id=1631#pack_2093">Results </a> : Results files for all simulations. Three packages can be found below that are related to different simulations: 1) unimpaired walking at many target speeds and self-selected speed; 2) walking with plantarflexor weakness; and 3) walking with plantarflexor contracture. Please refer to the descriptions below and the README.txt files in each package for more details. </li> <li> <a href="https://simtk.org/frs?group_id=1631#pack_2098">SCONE setup files </a> : Setup files to re-run optimizations starting with the optimized parameters from the paper. These are useful for preforming future studies, or re-optimizing for solutions in your own software environment. </li> <li> <a href="https://simtk.org/frs?group_id=1631#pack_2094">Docker files </a> : All files needed to build a Docker image and to regenerate the states files for most simulations. Please refer to the descriptions below and the README.txt files in each package for more details. </li> </ul>

运用优化框架（SCONE）和骨骼肌建模软件包（OpenSim），我们生成了多种速度下的行走真实模拟。随后，我们对踝关节背屈肌群的肌肉虚弱或挛缩进行了建模，以探究这些缺陷如何导致观察到的步态变化。本项研究提供了所有模拟的结果。此外，我们还提供了Docker构建指南和SCONE配置文件，以便他人能够复现我们的研究结果。

本项研究包含以下软件/数据包：

<ul>
<li>结果文件：<a href="https://simtk.org/frs?group_id=1631#pack_2093">结果</a>：所有模拟的结果文件。以下三个包分别与不同模拟相关：1）多种目标速度和自选速度下的无障碍行走；2）踝关节背屈肌群虚弱时的行走；3）踝关节背屈肌群挛缩时的行走。请参考以下描述和每个包中的README.txt文件以获取更多详细信息。</li>
<li>SCONE配置文件：<a href="https://simtk.org/frs?group_id=1631#pack_2098">SCONE配置文件</a>：从论文中的优化参数开始重新运行优化的配置文件。这些文件对于进行未来研究或在自己的软件环境中重新优化解决方案非常有用。</li>
<li>Docker文件：<a href="https://simtk.org/frs?group_id=1631#pack_2094">Docker文件</a>：构建Docker镜像和重新生成大多数模拟的状态文件所需的所有文件。请参考以下描述和每个包中的README.txt文件以获取更多详细信息。</li>
</ul>