Activity of human neural crest enhancer near BMPER in E11.5 transgenic mouse embryo - Tg(hg38_chr7:33486073-33487607::LacZ)

Tg(hg38_chr7:33486073-33487607::LacZ) human neural crest enhancer primarily exhibiting expression in the trigeminal ganglion and nerve. 2/8 embryos also express LacZ in the medial frontonasal prominence, periocular mesenchyme, branchial arches, forelimb buds, and somites. This enhancer has relatively low expression in the human frontonasal prominence, demonstrating a species-specific bias in P. troglodytes when these two species are compared.

Tg(hg38_chr7:33486073-33487607::LacZ) 是定位在人类参考基因组hg38的7号染色体33486073至33487607位点、融合LacZ报告基因的人类神经嵴（neural crest）增强子（enhancer），其主要在三叉神经节（trigeminal ganglion）及神经组织中表达。
8枚胚胎中有2枚还可在额鼻突内侧、眼周间充质（periocular mesenchyme）、鳃弓（branchial arches）、前肢芽（forelimb buds）及体节（somites）中检测到LacZ的表达。
该增强子在人类额鼻突（frontonasal prominence）中的表达水平相对较低，当对比人类与黑猩猩（Pan troglodytes）两个物种时，可观察到其在黑猩猩中存在物种特异性的表达偏向。