Pharmacokinetics profile of Lactodoxonano, Apodoxonano and Doxo.

Values in the parenthesis indicates the concentration of doxorubicin in micrograms per ml of blood/per gram of tissue;*value of t1/2β.Pharmacokinetic parameters.AUC: The integral of the concentration-time curve (after a single dose or in steady state).AUMC: Partial area under the moment curve between t start and t end.t ½: The time required for the concentration of the drug to reach half of its original value. In serum, t1/2α is referred duirngdistribution phase and t1/2β during elimination phases.Cmax :The peak plasma concentration of a drug after IV administration.Tmax :Time to reach Cmax.

括号内的数值表示阿霉素（doxorubicin）的浓度，单位为每毫升血液/每克组织中的微克数；*代表t1/2β的数值。药代动力学参数（Pharmacokinetic parameters）：AUC：血药浓度-时间曲线下面积（单次给药或稳态给药后）；AUMC：t起始时刻至t终止时刻之间的矩量曲线下部分面积；t½：药物浓度降至初始值一半所需的时间。在血清中，t1/2α对应分布相，t1/2β对应消除相；Cmax：静脉给药后药物的峰血浆浓度；Tmax：达到Cmax所需的时间。