Influenza H3 hemagglutinin vaccine with scrambled immunodominant epitopes elicits antibodies directed toward immunosubdominant head epitopes.

Here, the authors designed an H3 HA vaccine antigen with various amino acids at immunodominant epitopes of the HA head domain, termed scrambled HA (scrHA).

本研究中，作者设计了一种H3亚型血凝素（hemagglutinin, HA）疫苗抗原，该抗原在其头部结构域的免疫显性表位处引入了多种不同氨基酸，被命名为scrambled HA（scrHA）。