Table 2_Identifying the correlation between the number of OGTT abnormalities and perinatal outcomes in twin pregnancies: a retrospective cohort study.docx

IntroductionGestational diabetes mellitus (GDM) is a common metabolic disorder during pregnancy and is particularly significant in twin pregnancies due to their inherently higher risk of adverse perinatal outcomes. Identifying the correlation between the degree of glucose intolerance and perinatal outcomes can provide valuable insights for clinical management. This study aimed to investigate the risk of developing adverse perinatal outcomes in pregnant women and fetuses with twin births by the number of abnormal values of oral 75 g glucose tolerance test (OGTT).
MethodsWe conducted a population-based retrospective cohort study in which 3545 pregnant women with twin pregnancies in Women’s and Children’s Hospital of Chongqing Medical University underwent an oral 75 g glucose tolerance test to collect fasting, 1-hour postprandial, and 2-hour postprandial glucose, and to collect the perinatal outcomes of pregnant women and fetuses in the set.
ResultsLogistic regression analysis showed that the number of abnormal OGTTs was associated with the risk of expected adverse perinatal outcomes. In the unadjusted model, the prevalence of gestational hypertension, intrahepatic cholestasis in pregnancy, and hypoproteinemia in pregnancy were statistically significant. In the adjusted model, the prevalence of gestational hypertension and intrahepatic cholestasis in pregnancy was statistically significant.
ConclusionsThe number of abnormal OGTTs was associated with the incidence of gestational hypertension and intrahepatic cholestasis in pregnancy in twin pregnancies that had undergone assisted reproduction. These findings highlight the importance of closely monitoring glucose levels in such pregnancies to mitigate associated risks.

引言
妊娠期糖尿病（Gestational diabetes mellitus, GDM）是妊娠期常见的代谢紊乱性疾病，双胎妊娠因本身不良围产结局风险更高，因此该疾病在双胎妊娠群体中尤为值得关注。明确葡萄糖耐量异常程度与围产结局的关联，可为临床管理提供有价值的参考依据。本研究旨在基于口服75g葡萄糖耐量试验（oral 75 g glucose tolerance test, OGTT）的异常值数量，探究双胎妊娠孕妇及胎儿发生不良围产结局的风险。

方法
本研究开展了一项基于人群的回顾性队列研究，纳入重庆医科大学附属妇女儿童医院的3545名双胎妊娠孕妇，对其实施口服75g葡萄糖耐量试验，采集空腹血糖、餐后1小时血糖及餐后2小时血糖数据，并收集该队列中孕妇及胎儿的围产结局信息。

结果
Logistic回归分析显示，OGTT异常值数量与预期的不良围产结局风险存在关联。在未校正模型中，妊娠期高血压、妊娠期肝内胆汁淤积症及妊娠期低蛋白血症的患病率具有统计学显著性；在校正模型中，妊娠期高血压与妊娠期肝内胆汁淤积症的患病率仍具有统计学显著性。

结论
对于接受辅助生殖的双胎妊娠孕妇，OGTT异常值数量与妊娠期高血压及妊娠期肝内胆汁淤积症的发生率存在关联。本研究结果凸显了对此类妊娠群体密切监测血糖水平、降低相关并发症风险的重要性。