PD5D_MTG_Visium10x_ST

This Zenodo deposit contains a publicly available description of the Dataset: Title: "PD5D_MTG_Visium10x_ST". Description: Visium 10x spatial transcriptomic raw data in FASTQ format of the middle temporal gyrus of 96 human subjects. Individuals with incidental Lewy body disease, clinical PD, and healthy control were included. In addition to subject level metadata, Visium spatial metadata such as H&E images and spot coordinates are included. These data are one component of the PD5D cohort, which intends to build a multi-dimensional and multi-omic atlas of PD pathology. For the same subjects, other omics assays have been collected including genotyping, snRNA-seq, and scATAC-seq across two brain tissues: middle temporal gyrus and substantia nigra. This dataset is made available to researchers via the ASAP CRN Cloud: cloud.parkinsonsroadmap.org. Instructions for how to request access can be found in the User Manual. This research was funded by the Aligning Science Across Parkinson's Collaborative Research Network (ASAP CRN), through the Michael J. Fox Foundation for Parkinson's Research (MJFF). This Zenodo deposit was created by the ASAP CRN Cloud staff on behalf of the dataset authors. It provides a citable reference for a CRN Cloud Dataset Version bump from 1.0 to 1.1 The updated Datasets fix inconsistencies in the ASAP assigned `ASAP_subject_id` and `ASAP_sample_id` for these previously released PMDBS Datasets. These erroneously included the string "PMBDS", now replaced with "PMDBS". This change does not affect the underlying data files, but does update the metadata to be consistent with the naming convention used for all other PMDBS Datasets and the corresponding CDEs.本Zenodo存档包含某数据集的公开说明： 数据集标题："PD5D_MTG_Visium10x_ST"。 数据集说明：采用FASTQ格式存储的96名人类受试者颞中回的Visium 10x空间转录组原始数据。纳入人群包括偶发性路易体病患者、临床确诊帕金森病（Parkinson's Disease, PD）患者及健康对照者。除受试者层面的元数据外，本数据集还包含Visium空间元数据，例如苏木精-伊红（Hematoxylin and Eosin, H&E）染色图像及斑点坐标。该数据为PD5D队列的组成部分之一，该队列旨在构建帕金森病病理特征的多维度多组学图谱。针对同一批受试者，研究团队还在两处脑组织（颞中回与黑质）中采集了其他组学检测数据，包括基因分型、单细胞核RNA测序（single nuclear RNA sequencing, snRNA-seq）及单细胞转座酶可及性测序（single-cell Assay for Transposase-Accessible Chromatin sequencing, scATAC-seq）。 本数据集通过ASAP协作研究网络（Aligning Science Across Parkinson's Collaborative Research Network, ASAP CRN）云平台（cloud.parkinsonsroadmap.org）向研究人员开放获取，申请访问的具体流程可参阅用户手册。 本研究由"帕金森病研究科学协同网络"（Aligning Science Across Parkinson's Collaborative Research Network, ASAP CRN）通过迈克尔·J·福克斯帕金森病研究基金会（Michael J. Fox Foundation for Parkinson's Research, MJFF）资助。 本Zenodo存档由ASAP CRN云平台工作人员代表数据集作者创建，旨在为CRN云平台数据集提供可引用的文献标识。 本数据集版本已从1.0更新至1.1。更新后的数据集修正了此前发布的PMDBS数据集的ASAP分配编号`ASAP_subject_id`与`ASAP_sample_id`中存在的不一致问题：原编号中错误包含的字符串"PMBDS"现已替换为"PMDBS"。此次修改未对底层数据文件造成影响，仅更新了元数据，使其与所有其他PMDBS数据集及对应公共数据元素（Common Data Elements, CDEs）的命名规范保持一致。