Anergic CD8+ T cells with lower levels of IL-7 receptor α (Illumina)

We investigated the entity of IL-7Rα low effector memory (EM) CD8+ T cells in healthy individuals and finally uncovered that they were unable to proliferate and produce IL-2 in response to TCR stimulation Total RNA obtained from human IL-7Rα high and low effector memory (EM) CD8+ T cells in fresh or IL-2 reversed state.

我们针对健康个体中白细胞介素-7受体α链（IL-7Rα）低表达的效应记忆（EM）CD8+ T细胞的表型特征开展了研究，最终发现这类细胞在T细胞受体（TCR）刺激下无法增殖，也无法产生白细胞介素-2（IL-2）。本数据集的总RNA提取自新鲜状态或经IL-2逆转处理的人类IL-7Rα高表达与低表达效应记忆CD8+ T细胞。