Talaromyces marneffei suppresses macrophage inflammation by regulating host alternative splicing

To investigate the function of NCOR2-013 in T. marneffei-infected THP-1 macrophages, we established NCOR2-013 overexpression THP-1 macrphages. We then performed gene expression profiling analysis using data obtained from RNA-seq of T. marneffei-infected NCOR2-013 overexpression THP-1 macrophages and T. marneffei-infected control cells. Comparative gene expression profiling analysis of RNA-seq data for T. marneffei-infected NCOR2-013 overexpression THP-1 macrophages and T. marneffei-infected control cells.

为探究NCOR2-013在T. marneffei（马尔尼菲青霉菌）感染的THP-1巨噬细胞中的功能，我们构建了过表达NCOR2-013的THP-1巨噬细胞。随后，我们针对T. marneffei感染的过表达NCOR2-013的THP-1巨噬细胞与T. marneffei感染的对照细胞的RNA测序（RNA-seq）数据开展基因表达谱分析。本数据集针对上述两组细胞的RNA-seq数据，完成了基因表达谱的比较分析。