Dataset from Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be

NuMoM2b studied underlying, interrelated, mechanisms of adverse pregnancy outcomes (e.g., preterm birth, preeclampsia, fetal growth restriction) in pregnant women with no previous pregnancy lasting 20 weeks-0 days or more estimated gestational age (nulliparas). The network included 8 clinical sites, subsites, NICHD, and a data center. Women enrolled early in pregnancy and were followed through delivery, with study visits at 6 weeks-0 days to 13 weeks-6 days, 16 weeks-0 days to 21 weeks-6 days, 22 weeks-0 days to 29 weeks-6 days gestation, and delivery. Data collected through interviews, self-administered questionnaires, clinical measurements, ultrasounds, and medical records review included demographic, psychosocial, dietary, physiologic, health, and pregnancy outcome information. Subsets of participants enrolled in sleep disordered breathing, sleep patterns and quality, and fetal adrenal gland substudies.

NuMoM2b研究旨在探究无既往妊娠达20周0天及以上估算胎龄的初产妇（nulliparas）发生不良妊娠结局（如早产、子痫前期、胎儿生长受限）的潜在内在关联机制。该研究网络涵盖8个临床站点、分站点、美国国立儿童健康与人类发育研究所（NICHD）及1个数据中心。研究对象于妊娠早期入组，全程随访至分娩，随访时点分别为妊娠6周0天至13周6天、16周0天至21周6天、22周0天至29周6天，以及分娩当日。研究通过访谈、自填式问卷、临床测量、超声检查及病历审查等方式收集数据，内容涵盖人口统计学特征、社会心理状况、饮食情况、生理指标、健康状态及妊娠结局相关信息。另有部分参与者参与了睡眠呼吸障碍、睡眠模式与质量，以及胎儿肾上腺相关亚研究。