Results of sensitivity analyses on ethnic groups.

IntroductionThe aim of this paper is to investigate what factors are associated to cardiovascular disease and what differences exists between Asians living in the UK (from the English Longitudinal Study of Ageing) and the Asians living in India (from the Longitudinal Ageing Study in India).MethodsLogistic regression was used to investigate how demographic and physical performance factors were associated with cardiovascular disease using data from Wave 6 of the English Longitudinal Study of Ageing and Wave 1 of the Longitudinal Study of Ageing in India, with the main variable of interest being country of residence, Asians in England or Asians in India.ResultsA total of 83,997 participants were included in the analyses. In the primary analysis, 73,396 participants from LASI were compared to 171 Asians in ELSA. After adjusting for age, blood pressure, resting heart rate, sex, waist circumference, gait, handgrip strength and standing balance, there was a statistically significant difference for the outcome of CVD between Whites ELSA (reference) and the participants of LASI (odds ratio = 0.77; 95% confidence interval = 0.60 to 0.99). There were no significant differences in CVD between the LASI participants, Asian ELSA, and the Non-White but not Asian ELSA groups.DiscussionNo difference was found between Asians that live in India compared to ethnic minorities living in England, including Asians, after adjusting for confounders, but was found between Whites in ELSA compared to LASI participants. A key limitation was the massive disparity in sample sizes between the ELSA subgroups and LASI. Further work is required where comparable sample sizes and longitudinal analyses allow trends to be identified and to investigate the factors associated with the difference in CVD between two similar ethnicities living in distinct locations.ConclusionAfter adjusting for risk factors, there was no difference in CVD between localised Asians and the ethnic minorities in the UK, but there was a difference between the majority ethnicities in the respective countries.引言 本研究旨在探讨与心血管疾病相关的影响因素，并对比居住在英国的亚裔（数据源自英国老龄化纵向研究（English Longitudinal Study of Ageing, ELSA））与居住在印度的亚裔（数据源自印度老龄化纵向研究（Longitudinal Ageing Study in India, LASI））之间的差异。 方法 本研究采用logistic回归（Logistic regression）模型，利用英国老龄化纵向研究第6波与印度老龄化纵向研究第1波的数据，探讨人口统计学特征与身体机能指标与心血管疾病的关联，核心关注变量为居住国家：英国亚裔与印度亚裔。 结果 本研究共纳入83997名研究对象。初步分析中，将印度老龄化纵向研究的73396名参与者与英国老龄化纵向研究的171名亚裔参与者进行对比。在校正年龄、血压、静息心率、性别、腰围、步态、握力与站立平衡能力等混杂因素后，以英国老龄化纵向研究中的白人参与者为参照组，印度老龄化纵向研究参与者的心血管疾病发病风险存在统计学显著性差异（比值比（odds ratio）=0.77；95%置信区间（confidence interval）：0.60~0.99）。而印度老龄化纵向研究参与者、英国老龄化纵向研究中的亚裔参与者，以及英国老龄化纵向研究中的非白人非亚裔群体之间，心血管疾病发病风险无显著差异。 讨论 在校正混杂因素后，居住在印度的亚裔与英国境内的少数族裔（包括亚裔）之间的心血管疾病发病风险未发现显著差异，但英国老龄化纵向研究中的白人参与者与印度老龄化纵向研究参与者之间存在显著差异。本研究的关键局限性在于英国老龄化纵向研究各亚组与印度老龄化纵向研究的样本量存在巨大差异。未来需开展样本量可比的研究，并采用纵向分析方法以明确相关趋势，进一步探讨居住在不同国家的同种族群体之间心血管疾病发病差异的影响因素。 结论 在校正风险因素后，英国境内的亚裔与当地少数族裔的心血管疾病发病风险无显著差异，但两国主体民族群体之间的心血管疾病发病风险存在显著差异。