Additional file 7 of Modulation of innate immunity related genes resulting in prophylactic antimicrobial and antiviral properties

Additional file 7. Related to Figure S2B. Biological processes related to the proteins of the interaction network generated via the Search Tool for the Retrieval of Interacting Genes/ Proteins (STRING) database ( https://string-db.org ) by using proteins encoded by those DEGs taking part to ‘pathway in cancer’ in KEGG pathway enrichment analyses performed on RNAseq data obtained from Caco-2 cells treated with Solution-3 (0.01x) or vehicle (0.8% NaCl) for 24 hours (see Additional file 5-6). The proteins belonging to biological processes involved in immune system and inflammation are indicated in bold: positive regulation of immune system process (GO:0002684, fdr = 0.0011), inflammatory response (GO:0006954, fdr = 0.0049), leukocyte differentiation (GO:0002521, fdr = 0.0051), regulation of T cell differentiation in thymus (GO:0033081, fdr = 0.0057), response to cytokine (GO:0034097, false discovery rate [fdr] = 0.0107), mononuclear cell differentiation (GO:1903131, fdr = 0.0110) regulation of phagocytosis (GO:0050764, fdr = 0.0112), cytokine-mediated signaling pathway (GO:0019221, fdr = 0.0197), cellular response to cytokine stimulus (GO:0071345, fdr = 0.0208), myeloid leukocyte differentiation (GO:0002573, fdr = 0.0228), leukocyte migration (GO:0050900, fdr = 0.0236), positive regulation of T cell differentiation in thymus (GO:0033089, fdr = 0.0268), regulation of leukocyte activation (GO:0002694, fdr = 0.0342), alpha-beta T cell differentiation (GO:0046632, fdr = 0.0394), T cell differentiation (GO:0030217, fdr = 0.0433) and positive regulation of phagocytosis (GO:0050766, fdr = 0.0448). The term ID, the term description, the observed gene count, the background gene count, the strength, the false discovery rate (frd) and the matching proteins in the network are shown.

附加文件7。本文件与图S2B相关。其内容聚焦于通过检索相互作用基因/蛋白质搜索工具（Search Tool for the Retrieval of Interacting Genes/Proteins，STRING）数据库（https://string-db.org）构建的相互作用网络的蛋白质所涉及的生物学过程。这些蛋白质源自对经Solution-3（0.01倍稀释）或对照溶剂（0.8%氯化钠）处理24小时的Caco-2细胞的RNA测序数据进行KEGG通路富集分析后，参与“癌症通路”的差异表达基因（differentially expressed genes，DEGs）所编码的蛋白质（详见附加文件5-6）。其中参与免疫系统与炎症相关生物学过程的蛋白质已以粗体标注，具体包括：免疫系统过程正调控（GO:0002684，错误发现率（false discovery rate, FDR）=0.0011）、炎症应答（GO:0006954，FDR=0.0049）、白细胞分化（GO:0002521，FDR=0.0051）、胸腺T细胞分化调控（GO:0033081，FDR=0.0057）、细胞因子应答（GO:0034097，FDR=0.0107）、单核细胞分化（GO:1903131，FDR=0.0110）、吞噬作用调控（GO:0050764，FDR=0.0112）、细胞因子介导的信号通路（GO:0019221，FDR=0.0197）、细胞对细胞因子刺激的应答（GO:0071345，FDR=0.0208）、髓系白细胞分化（GO:0002573，FDR=0.0228）、白细胞迁移（GO:0050900，FDR=0.0236）、胸腺T细胞分化正调控（GO:0033089，FDR=0.0268）、白细胞活化调控（GO:0002694，FDR=0.0342）、αβ T细胞分化（GO:0046632，FDR=0.0394）、T细胞分化（GO:0030217，FDR=0.0433）以及吞噬作用正调控（GO:0050766，FDR=0.0448）。本内容将展示各分析条目的术语ID、术语描述、观测基因数、背景基因数、富集强度、错误发现率（FDR）以及该相互作用网络中的匹配蛋白质。