COMPLEXO: identifying the missing heritability of breast cancer via next generation collaboration

Coordinated international collaboration offers great potential to advance the discovery of additional breast cancer susceptibility genes. COMPLEXO was established to facilitate collaborations between researchers actively applying massively parallel sequencing to further understand the genetics of breast and ovarian cancer. COMPLEXO has 38 member Institutions (spanning 23 countries) and more than 1,000 combined human exomes from women at high risk of breast cancer. The consortium defined activities and brought together data and resources suitable for exome/genome sequencing initiatives and large case-control-family study resources suitable for validation of candidate susceptibility genes in which rare mutations are associated with high to moderate risk of breast cancer. Publication this data set supports:COMPLEXO, Southey MC, Park DJ, Nguyen-Dumont T, Campbell I, Thompson E, Trainer AH, Chenevix-Trench G, Simard J, Dumont M, Soucy P, Thomassen M, Jønson L, Pedersen IS, Hansen TV, Nevanlinna H, Khan S, Sinilnikova O, Mazoyer S, Lesueur F, Damiola F, Schmutzler R, Meindl A, Hahnen E, Dufault MR, Chris Chan T, Kwong A, Barkardóttir R, Radice P, Peterlongo P, Devilee P, Hilbers F, Benitez J, Kvist A, Törngren T, Easton D, Hunter D, Lindstrom S, Kraft P, Zheng W, Gao YT, Long J, Ramus S, Feng BJ, Weitzel JN, Nathanson K, Offit K, Joseph V, Robson M, Schrader K, Wang S, Kim YC, Lynch H, Snyder C, Tavtigian S, Neuhausen S, Couch FJ, Goldgar DE. COMPLEXO: identifying the missing heritability of breast cancer via next generation collaboration. Breast Cancer Res. 2013 Jun 21;15(3):402. doi: 10.1186/bcr3434. PMID: 23809231; PMCID: PMC3706918.

协调国际间的合作具有极大潜力以推进乳腺癌易感基因的发现。COMPLEXO项目的设立旨在促进积极应用大规模并行测序技术研究乳腺癌和卵巢癌遗传学的研究人员之间的协作。COMPLEXO拥有来自23个国家的38个成员机构，以及超过1000例具有较高乳腺癌风险女性的联合外显子组。该联盟明确了活动内容，并汇集了适用于外显子/基因组测序项目的相关数据与资源，以及适用于验证候选易感基因的病例对照-家族研究资源，其中罕见的突变与乳腺癌的高至中等风险相关。本数据集的发布支持了以下论文：COMPLEXO, Southey MC, Park DJ, Nguyen-Dumont T, Campbell I, Thompson E, Trainer AH, Chenevix-Trench G, Simard J, Dumont M, Soucy P, Thomassen M, Jønson L, Pedersen IS, Hansen TV, Nevanlinna H, Khan S, Sinilnikova O, Mazoyer S, Lesueur F, Damiola F, Schmutzler R, Meindl A, Hahnen E, Dufault MR, Chris Chan T, Kwong A, Barkardóttir R, Radice P, Peterlongo P, Devilee P, Hilbers F, Benitez J, Kvist A, Törngren T, Easton D, Hunter D, Lindstrom S, Kraft P, Zheng W, Gao YT, Long J, Ramus S, Feng BJ, Weitzel JN, Nathanson K, Offit K, Joseph V, Robson M, Schrader K, Wang S, Kim YC, Lynch H, Snyder C, Tavtigian S, Neuhausen S, Couch FJ, Goldgar DE. COMPLEXO: 通过下一代合作识别乳腺癌的缺失遗传性。乳腺癌研究。2013年6月21日；15(3):402。DOI: 10.1186/bcr3434。PMID: 23809231；PMCID: PMC3706918。