RNA sequencing of control and dystrophin-mutant engineered heart tissues from human induced pluripotent stem cell-derived cardiomyocytes

We report the transcriptomic differences between engineered heart tissues generated from hiPSCs with a dystrophin-truncating mutation and an isogenic control. We find that the dystrophin mutation induces profound differences at the transcriptomic level and illuminates potential disease-causing mechanisms. RNA sequencing of control and dystrophic engineered heart tissues

本研究报道了携带肌营养不良蛋白截短突变的人类诱导多能干细胞（human induced pluripotent stem cells，hiPSCs）所构建的工程化心脏组织，与同基因对照工程化心脏组织之间的转录组差异。研究发现，该肌营养不良蛋白截短突变可在转录组层面引发显著差异，并阐明了潜在的致病机制。针对对照组与肌营养不良型工程化心脏组织的RNA测序。