miRNA expression profiling in early stage breast cancer

MiRNA profiling from whole blood (EDTA) was used to identify a miRNA profile applicable for early stage breast cancer detection In the study presented here, a consecutively collected, well-defined cohort of 48 patients with early stage breast cancer (invasive ductal carcinoma) at diagnosis was compared with a cohort of 57 healthy individuals for known homo sapiens miRNAs (mirbase 15).

本研究通过乙二胺四乙酸(EDTA)抗凝全血的miRNA表达谱分析，筛选可用于早期乳腺癌检测的miRNA特征。在本次研究中，我们将连续入组、特征明确的48例确诊早期乳腺癌（浸润性导管癌）患者队列，与57例健康个体队列，针对miRBase 15数据库收录的已知智人miRNA开展了对比分析。