Structure of GluK1 ligand-binding domain (S1S2) in complex with (2S,4R)-4-(2-carboxyphenoxy)pyrrolidine-2-carboxylic acid at 3.18 A resolution

Protein Data Bank Japan2024-10-23 更新2026-03-21 收录

下载链接：

https://pdbj.org/mine/summary/5m2v

下载链接

链接失效反馈

官方服务：

资源简介：

Structure of GluK1 ligand-binding domain (S1S2) in complex with (2S,4R)-4-(2-carboxyphenoxy)pyrrolidine-2-carboxylic acid at 3.18 A resolution Descriptor: (2~{S},4~{R})-4-(2-carboxyphenoxy)pyrrolidine-2-carboxylic acid, CHLORIDE ION, Glutamate receptor ionotropic, ... Authors: Frydenvang, K, Kastrup, J.S, Kristensen, C.M. Deposit date: 2016-10-13 Release date: 2017-01-11 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (3.18 Å) Cite: Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid. J. Med. Chem., 60, 2017

分辨率为3.18埃的GluK1配体结合结构域（S1S2）与(2S,4R)-4-(2-羧基苯氧基)吡咯烷-2-羧酸的复合物结构描述项：(2S,4R)-4-(2-羧基苯氧基)吡咯烷-2-羧酸、氯离子、离子型谷氨酸受体…… 作者：Frydenvang K、Kastrup J.S.、Kristensen C.M. 提交日期：2016-10-13 发布日期：2017-01-11 最后修改日期：2024-10-23 实验方法：X射线衍射（3.18 Å）引用文献：《一系列L-反式-4-取代脯氨酸的设计与合成：作为离子型谷氨酸受体的选择性拮抗剂——含新型亚型选择性红藻氨酸受体1型（GluK1）拮抗剂(2S,4R)-4-(2-羧基苯氧基)吡咯烷-2-羧酸的功能与X射线晶体学研究》，《药物化学杂志》（J. Med. Chem.），第60卷，2017年

创建时间：

2016-10-13