Differential Recruitment of the Splicing Machinery during Transcription Predicts Genome-wide Patterns of mRNA Splicing

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The splicing machinery associates with genes to facilitate efficient co-transcriptional mRNA processing

Detained introns are novel, widespread class of posttranscriptionally-spliced introns

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Removal of introns by pre-mRNA splicing is a critical and in some cases rate-limiting step in mammalian gene expression. Deep sequencing of mouse embryonic stem cell RNA revealed many specific intern

干细胞与再生医学数据中心2022-02-20 更新110

Data_Sheet_1_Cotranscriptional and Posttranscriptional Features of the Transcriptome in Soybean Shoot Apex and Leaf.XLSX

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Transcription is the first step of central dogma, in which the genetic information stored in DNA is copied into RNA. In addition to mature RNA sequencing (RNA-seq), high-throughput nascent RNA assays

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The Exon Junction Complex coordinates the co-transcriptional inclusion of blocks of neighboring exons

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The Exon Junction Complex (EJC) has roles in mRNA export and cytoplasmic quality control. Yet EJC is recruited to pre-mRNA by the spliceosome, prior to the second catalytic step of splicing. Because s

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Wide spread and efficient co-transcriptional splicing facilitated by multiple exons. Wide spread and efficient co-transcriptional splicing facilitated by multiple exons

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Pre-mRNA splicing is important for gene expression in most eukaryotic organisms. Regulation occurs during pre-mRNA splicing greatly expanded the transcriptome complexity. Recent studies from Mammals,

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Global co-transcriptional splicing in Arabidopsis and the correlation with splicing regulation in mature RNAs. Global co-transcriptional splicing in Arabidopsis and the correlation with splicing regulation in mature RNAs

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RNA splicing and spliceosome assembly in eukaryotes occur mainly during transcription. However, co-transcriptional splicing has not yet been explored in plants. Here, we showed that in Arabidopsis tha

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Differential Recruitment of the Splicing Machinery during Transcription Predicts Genome-wide Patterns of mRNA Splicing

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