Dataset related to article "A 'Multiomic' Approach of Saliva Metabolomics, Microbiota, and Serum Biomarkers to Assess the Need of Hospitalization in COVID-19"

*These authors contributed equally to the work    #Corresponding author

This record contains raw data related to article “A ‘Multiomic’ Approach of Saliva Metabolomics, Microbiota, and Serum Biomarkers to Assess the Need of Hospitalization in COVID-19"

Abstract:

The SARS-CoV-2 pandemic has overwhelmed the treatment capacity of the healthcare systems during the highest viral diffusion rate. Patients reaching the emergency department had to be either hospitalized or discharged. Still, the decision was taken based on the individual assessment of the  actual clinical condition, without specific biomarkers to predict future improvement or deterioration. Often discharged patients returned to the hospital for aggravation of their condition. Here we have developed a new combined approach of omics to identify factors that could distinguish COVID-19 inpatients from outpatients. We tested the metabolome in the saliva and identified nine metabolites that separated the inpatient from the outpatient population, but not completely. When combined with serum biomarkers, just two salivary metabolites (myo-inositol and 2-pyrollidine acetic acid) and one serum protein, Chitinase 3-like-1(CHI3L1) were sufficient to separate the two groups completely. These metabolites positively or negatively correlated with four modulated microbiota taxa. This is a proof-of-concept that a combined omic analysis can be used to stratify patients.

* 本文作者对本工作贡献均等 # 通讯作者

本数据集包含与论文《基于唾液代谢组学、微生物组学与血清生物标志物的多组学方法评估新冠患者住院必要性》相关的原始数据

摘要：

严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）引发的疫情在病毒传播峰值期远超全球医疗系统的收治能力。就诊于急诊科的新冠患者需被判定为收治入院或出院，但此类决策仅基于对患者实际临床状况的个体化评估，尚无特异性生物标志物可预测病情后续的好转或恶化。常有出院患者因病情加重再次返院就诊。本研究开发了一种新型整合组学分析方法，以筛选可区分新冠住院患者与门诊患者的相关因素。我们对唾液代谢组进行检测，筛选出9种可区分住院与门诊人群的代谢物，但该区分效果并不完全。当联合血清生物标志物进行分析时，仅需2种唾液代谢物（肌醇与2-吡咯烷乙酸）及1种血清蛋白——几丁质酶3样蛋白1（CHI3L1），即可完全区分两组患者。上述代谢物与4种经调控的微生物类群呈显著正相关或负相关。本研究证实整合组学分析可用于新冠患者的分层管理，为一项概念验证性研究。