Expression data (micro-array, frozen tumors) from various sarcomas

We validated the technological and material transfers of the CINSARC signature. We performed both microarray and RNA-seq analysis and compared prognostic values based on the CINSARC classification. We measure significant metastasis-free survivals with both approaches. Additionally, depending on RNA degradation, transcriptomic analysis from FFPE blocks show similar CINSARC classification.

我们对CINSARC特征标记（CINSARC signature）的技术与材料转移流程进行了验证。本研究同时开展了基因芯片（microarray）与RNA测序（RNA-seq）分析，并基于CINSARC分类体系对比了两种方法的预后价值。结果证实，两种分析方法均能检测到具有统计学意义的无转移生存期（metastasis-free survival）差异。此外，针对不同RNA降解程度的福尔马林固定石蜡包埋（FFPE）组织块，其转录组分析（transcriptomic analysis）仍可得到一致性的CINSARC分类结果。