Erinaceolactones A to C, from the Culture Broth of <i>Hericium erinaceus</i>

Three novel compounds, erinaceolactones A to C (1–3), and a known compound (4) were isolated from the culture broth of Hericium erinaceus. The planar structures of 1–3 were determined by the interpretation of spectroscopic data. The absolute configuration of 3 was determined by X-ray crystallography. Although compound 4 had been synthesized, it was isolated from a natural source for the first time. In the bioassay examining plant-growth regulatory activity of these compounds (1–4) and other components of the fungus (5–8), compounds 1, 2, and 4–8 suppressed the growth of lettuce.本研究从猴头菇（Hericium erinaceus）的发酵培养液中，分离得到3个新型化合物——猴头内酯A~C（erinaceolactones A~C，1~3）以及1个已知化合物4。通过光谱数据解析，确定了化合物1~3的平面结构；化合物3的绝对构型经X射线晶体衍射法确证。尽管化合物4此前已有合成报道，但本研究首次从天然来源中分离得到该化合物。在针对化合物1~4及该真菌其他组分（5~8）的植物生长调节活性生物测定实验中，化合物1、2及4~8均可抑制生菜的生长。