Genome diversity and quorum sensing variations in laboratory strains of Pseudomonas aeruginosa PAO1. P. aeruginosa Spontaneous Mutation in Laboratory

We investigate the diversity of 5 P. aeruginosa PAO1 sublines and examine the effect of genomic diversity on quorum sensing through high throughput genomic sequence, virulence, and bioinformatic analysis. We obtained 4 sublines from our lab and 1 subline from the University of Washington (U.S.A.).

本研究围绕5株铜绿假单胞菌（Pseudomonas aeruginosa）PAO1亚株的多样性展开探究，并通过高通量基因组测序、毒力分析及生物信息学分析，考察基因组多样性对群体感应（quorum sensing）的影响。本研究从本实验室获取4株亚株，另从美国华盛顿大学获得1株亚株。