Structure of ScIRED-R2-V3 from Streptomyces clavuligerus in complex with 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole

Structure of ScIRED-R2-V3 from Streptomyces clavuligerus in complex with 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole Descriptor: 5-[2,5-bis(fluoranyl)phenyl]-3,4-dihydro-2~{H}-pyrrole, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Zhang, L.L, Liu, W.D, Shi, M, Huang, J.W, Yang, Y, Chen, C.C, Guo, R.T. Deposit date: 2022-06-24 Release date: 2023-06-28 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Engineered Imine Reductase for Larotrectinib Intermediate Manufacture Acs Catalysis, 12, 2022棒状链霉菌（Streptomyces clavuligerus）来源的ScIRED-R2-V3与5-(2,5-二氟苯基)-3,4-二氢-2H-吡咯形成复合物的晶体结构。配体及辅因子描述：5-[2,5-二氟苯基]-3,4-二氢-2H-吡咯、烟酰胺腺嘌呤二核苷酸磷酸（NADP）、还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH）……作者：张(L.L.)、刘(W.D.)、石(M.)、黄(J.W.)、杨(Y.)、陈(C.C.)、郭(R.T.)。存档日期：2022-06-24；发布日期：2023-06-28；最后修改日期：2023-11-29。实验方法：X射线衍射（分辨率2.41埃）。引用文献：《用于拉罗替尼中间体（Larotrectinib Intermediate）生产的工程化亚胺还原酶》，发表于《ACS催化（Acs Catalysis）》，第12卷，2022年。