Nickel-Catalyzed Asymmetric <i>C</i>‑Alkylation of Nitroalkanes: Synthesis of Enantioenriched β‑Nitroamides

A general catalytic method for asymmetric C-alkylation of nitroalkanes using nickel catalysis is described. This method enables the formation of highly enantioenriched β-nitroamides from readily available α-bromoamides using mild reaction conditions that are compatible with a wide range of functional groups. When combined with subsequent reactions, this method allows access to highly enantioenriched products with nitrogen-bearing fully substituted carbon centers.本研究报道了一种以镍催化（nickel catalysis）实现硝基烷烃（nitroalkanes）不对称碳烷基化（asymmetric C-alkylation）的通用催化方法。该方法可通过易得的α-溴代酰胺（α-bromoamides），在温和且兼容多种官能团（functional groups）的反应条件下，合成高对映体富集的β-硝基酰胺（β-nitroamides）。将该方法与后续反应联用，即可获得含有含氮全取代碳中心（fully substituted carbon centers）的高对映体富集产物。