Patterns of metastasis and recurrence in urothelial cancer molecular subtypes

This series contains the gene expression data from urothelial bladder cancer samples from Swedish patients that were used to analyze metastatic sites. Included patients have a recurrence or distant metastasis before or after treatment with chemotherapy. Patients with only lymph-node metastases are not included. A previous series (GSE169455) contains data from all patients that recieved two or more cycles of neoadjuvant chemotherapy with curative intent. Patients in that series that developed distant recurrence are re-analyzed here. A few samples from a previous cystectomy series (GSE83586) are also included as re-analysis. In addition, the current series contains data from patients treated with palliative first-line chemotherapy, curative adjuvant chemotherapy, or < 2 cycles of neoadjuvant chemotherapy. Raw data should be adjusted in data processing for batch variables: Labeling batch and Labeling kit. Retrospective cohort study aiming to study metastatic sites and chemotherapy response in muscle-invasive bladder cancer.

本数据集系列包含来自瑞典患者的尿路上皮膀胱癌（urothelial bladder cancer）样本的基因表达数据，用于分析转移位点。纳入研究的患者在接受化疗前后均出现复发或远处转移；仅伴淋巴结转移的患者未被纳入本数据集。
此前的数据集系列（GSE169455）包含所有接受≥2个周期根治性新辅助化疗（neoadjuvant chemotherapy）患者的相关数据，本研究将对该系列中出现远处复发的患者样本进行重新分析。此外，本数据集还纳入了此前膀胱切除术（cystectomy）数据集系列（GSE83586）中的少量样本以开展重新分析。
本数据集同时包含接受姑息性一线化疗、根治性辅助化疗，或接受<2个周期新辅助化疗的患者的相关数据。原始数据在数据处理过程中需针对两类批次变量进行校正：标记批次（Labeling batch）与标记试剂盒（Labeling kit）。本研究为回顾性队列研究（retrospective cohort study），旨在探索肌层浸润性膀胱癌（muscle-invasive bladder cancer）的转移位点与化疗应答情况。