Smart ankle bracelet-laser device to improve gait and detect freezing of gait in Parkinsonism patients: a case series

Freezing of gait (FOG) is one of the most disabling symptoms of Parkinsonism. Moreover, it does not respond well to medication. Visual cues have been shown to alleviate FOG in Parkinsonism; however, their efficacy is inconsistent. Currently, most mobile cueing devices are used as an open-loop cueing system, which requires manual control to enable constant visual cues. Thus, such devices may not be suitable for some people, especially those who have attention deficits. In addition, objective measurements of FOG in real-life situations remain challenging. Therefore, we developed a smart-ankle laser as a closed-loop cueing system that can detect the patient’s walking pattern and automatically project a laser line that follows each walking step, thus requires less attention. Real-time motion was also recorded within the device for FOG measurement. We studied the efficacy of the device in three Parkinsonism patients with FOG (one man and two women, aged 58–76 years) immediately after use and two patients at 1-week follow-up. Gait speed, Timed Up and Go test performance, stride length, and % FOG improved with the use of the laser, without adverse effects.

步态冻结（Freezing of Gait, FOG）是帕金森综合征最具致残性的症状之一，且对药物治疗响应不佳。已有研究证实，视觉提示可缓解帕金森综合征患者的步态冻结症状，但其临床疗效并不稳定。当前多数移动式提示设备均采用开环提示系统架构，需手动操控以维持持续的视觉提示输出，因此这类设备并不适用于部分人群，尤其是存在注意力缺陷的患者。此外，在真实生活场景中对步态冻结进行客观量化仍存在较大挑战。为此，本研究团队开发了一款智能踝部激光闭环提示系统：该装置可实时识别患者的行走模式，并自动投射随行走步伐同步变化的激光标线，从而降低患者的注意力负担；该装置还内置实时运动记录功能，用于步态冻结的量化分析。本研究共纳入3名伴步态冻结症状的帕金森综合征患者（1男2女，年龄58~76岁），评估了装置即刻使用后的疗效，并对其中2名患者开展了为期1周的随访评估。使用该激光装置后，受试者的步行速度、计时起身行走测试（Timed Up and Go Test, TUG）表现、步长以及步态冻结占比（% FOG）均得到改善，且未出现任何不良反应。