Effect of depletion of Nucleoporin Seh1 on gene expression during proliferation and differentiation of neural stem cell

To investigate the function of Nucleoporin Seh1 in the regulation of neural stem cell proliferation and differentiation, we used cmv-cre-ert,seh1 inducible knockout mice's neural stem cell to find out different expression genes We then performed gene expression profiling analysis using data obtained from RNA-seq of 4 different cells at proliferation and differentiation stage.

为探究核孔蛋白Seh1（Nucleoporin Seh1）在神经干细胞增殖与分化调控中的功能，我们采用携带CMV-Cre-ERT的Seh1诱导性基因敲除小鼠的神经干细胞以筛选差异表达基因；随后基于4种不同细胞在增殖及分化阶段获取的RNA测序（RNA-seq）数据，开展基因表达谱分析。