BAG Montpellier

The BAG of Montpellier gathers researchers from distinct institutes (CBS, IGF, IRIM and LPHI) affiliated to the INSERM, the CNRS and the university of Montpellier. The CBS is a node of the national infrastructure FRISBI. In this context, it is developping new methodologies for efficient ligand screening by X-ray diffraction. It is also involved in solving the structure of novel therapeutic targets to develop novel drug candidates. The IGF is involved in characterizing membrane proteins (mainly GPCRs) in order to better understand their functioning for therapeutic application. The IRIM and LPHI are focusing on several therapeutic targets related to infectious diseases in order to identify and develop novel inhibitors. CBS and IGF use SAXS to unravel the organization and behavior of various macromolecular systems in solution. Finally, we also use cryo-electron microscopy to study some macromolecular assemblies.

蒙彼利埃BAG团队汇聚了隶属于法国国家健康与医学研究院（INSERM）、法国国家科学研究中心（CNRS）以及蒙彼利埃大学的四家不同研究所（CBS、IGF、IRIM与LPHI）的研究人员。其中CBS为国家级基础设施FRISBI的节点单位，在此背景下，该团队正开发基于X射线衍射的高效配体筛选新方法，同时致力于解析新型治疗靶点的三维结构以研发创新药物候选化合物。IGF则专注于膜蛋白（主要为G蛋白偶联受体，G protein-coupled receptors, GPCRs）的表征研究，以期深入阐明其功能机制并推动治疗应用。IRIM与LPHI则聚焦于多种与传染病相关的治疗靶点，旨在识别并开发新型抑制剂。CBS与IGF借助小角X射线散射（SAXS）技术解析溶液中各类大分子系统的组织形式与动态行为。此外，本团队还利用冷冻电子显微镜（cryo-electron microscopy）研究部分大分子复合物。