Forepaw electrical stimulation: MD and MK time-dependence vs. BOLD-fMRI

Data were acquired from female Wistar rats (N=10) using a 14.1T MRI system (Bruker BioSpin) and a home-built surface quadrature transceiver RF coil. The dataset includes: Diffusion-weighted images at five different diffusion times, acquired using the fast kurtosis approach (Hansen, Lund, et al., 2016; Hansen, Shemesh, et al., 2016), plus one reversed EPI phase-encode direction acquisition. BOLD-fMRI time series with a temporal resolution of 1 second plus one reversed EPI phase-encode direction acquisition. All rats underwent forepaw electrostimulation during five functional runs (only four for rats 000002 and 000003). Rest and stimulation intervals were structured as follows: Diffusion-weighted imaging (dwi): 14 images at rest, 14 during stimulation, repeated until a total of 84 images was reached (first b0 image excluded from the analysis). BOLD-fMRI (func): 28 images at rest, 28 during stimulation, repeated until a total of 336 images was obtained. Aim: Investigate how brain activity changes MD and MK values (at each diffusion time) but potentially also changes their diffusion time-dependence signature, which could provide additional insight into activity-driven microstructural changes. Quantifications in each region-of-interest were done in the left hemisphere and were reported as contralateral when the right forepaw was stimulated (expected response in the left primary somatosensory cortex), and ipsilateral when the left forepaw was stimulated (little to no response expected in left primary somatosensory cortex, as the main response should be in the right primary somatosensory cortex). If using this data, please cite the following article: https://doi.org/10.1162/imag_a_00445本数据集的数据采集自10只雌性Wistar大鼠（N=10），使用14.1T磁共振成像（MRI）系统（布鲁克BioSpin，Bruker BioSpin）及自制的表面正交收发射频线圈（RF coil）。数据集包含以下内容： 五种不同扩散时间的扩散加权成像（DWI）图像，采用快速峰度方法（Hansen、Lund等，2016；Hansen、Shemesh等，2016）采集，同时附带一次反向平面回波成像（EPI）相位编码方向采集。 时间分辨率为1秒的血氧水平依赖功能磁共振成像（BOLD-fMRI）时间序列，同样附带一次反向EPI相位编码方向采集。 所有大鼠在五次功能扫描过程中均接受前爪电刺激（仅大鼠000002与000003完成四次扫描）。静息期与刺激期的采集结构如下： 扩散加权成像（DWI）：静息状态下采集14幅图像，刺激状态下采集14幅图像，重复该流程直至总采集量达到84幅（分析阶段将剔除第一幅b0图像）。 BOLD-fMRI（func）：静息状态下采集28幅图像，刺激状态下采集28幅图像，重复该流程直至总采集量达到336幅。 本研究的目的为：探究脑活动如何改变各扩散时间下的平均扩散系数（MD）与平均峰度（MK）数值，同时还可能改变其扩散时间依赖特征，该特征可为揭示活动驱动的大脑微观结构变化提供额外视角。 所有感兴趣区（ROI）的量化分析均在左侧半球完成：当刺激右侧前爪时，量化结果记为对侧（此时左侧初级躯体感觉皮层预期会产生响应）；当刺激左侧前爪时，量化结果记为同侧（此时左侧初级躯体感觉皮层预期几乎无响应，主要响应应出现在右侧初级躯体感觉皮层）。 若使用本数据集，请引用以下文章：https://doi.org/10.1162/imag_a_00445