The authors engineer an anti-PD-1-concealed sIL-15 fusion protein (αPD-1-IL-15-R), eliciting extraordinary antitumor immunity with negligible toxicity. αPD-1-IL-15-R largely expands tumor-specific CD8

NIAID Data Ecosystem70

Gene expression profiling of CD4+ T-cell subsets in follicular lymphoma.

肿瘤免疫学

T细胞功能分析

CD4+ T-cells from three follicular lymphoma tumors were sorted by flow cytometry into three subsets based on high (hi), intermediate (int), or low (lo) levels of PD-1 and CXCR5 expression and whole ge

NIAID Data Ecosystem70

Attenuated-SIVmac239?nef Viral Sequencing

HIV免疫反应

T细胞受体

Different HIV/SIV vaccine vectors expressing the same viral antigens can elicit disparate T-cell responses. Within this spectrum, replicating variable vaccines like SIVmac239?nef appear to generate pa

NIAID Data Ecosystem80

B-cell gene expression and microbiota prior immunization profile vaccine humoral responsiveness. Skin/Stool microbiome

粪便微生物组

HIV免疫反应

Association of Skin/Stool response to immune response to HIV cutaneous vaccine

NIAID Data Ecosystem70