Pharmacokinetics parameters obtained from animals injected with a single dose of ceftiofur and PLGA-cef.

Note: Data represent the mean ± standard deviation of serum values in rats (n = 3 per group) injected with free ceftiofur (700 μg/kg of weight), and PLGA-cef microparticles (10 mg/kg of weight).Parameters: Cmax, maximal concentration; Tmax, time to maximal concentration; t1/2, elimination half-life; AUC, area under curve; α, constant of absorption; β, constant of elimination; A, rate constant representing slope of distribution; B, rate constant representing slope of elimination phase.*Values with statistically significant differences (PPharmacokinetics parameters obtained from animals injected with a single dose of ceftiofur and PLGA-cef.

注：本数据为各组大鼠（每组n=3）血清检测值的平均值±标准差，受试大鼠分别单次注射游离头孢噻呋（ceftiofur，700 μg/kg体重）与PLGA-cef微球（10 mg/kg体重）。
参数说明：Cmax（峰浓度，maximal concentration）、Tmax（达峰时间，time to maximal concentration）、t1/2（消除半衰期，elimination half-life）、AUC（曲线下面积，area under curve）、α（吸收速率常数，constant of absorption）、β（消除速率常数，constant of elimination）、A（代表分布相斜率的速率常数，rate constant representing slope of distribution）、B（代表消除相斜率的速率常数，rate constant representing slope of elimination phase）。
*具有统计学显著性差异的数值（原文此处P值相关标注存在缺失）；本药代动力学参数得自单次注射头孢噻呋与PLGA-cef制剂的大鼠。