Association between MCP-1 -2518A>G polymorphism and asthma susceptibility: a meta-analysis

The published data on the association between MCP-1 -2518A>G polymorphism and asthma susceptibility are inconclusive. Therefore, we performed a meta-analysis to estimate the impact of MCP-1 -2518A>G polymorphism on asthma susceptibility. PubMed, Web of Science, Wanfang, and China National Knowledge Infrastructure (CNKI) databases were used to identify eligible studies. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to calculate the strength of association. Sensitivity analysis was performed to evaluate the influence of individual studies on the estimates of overall effect, and funnel plots and Egger's test were used to assess publication bias. Eight publications with 1562 asthma patients and 1574 controls were finally identified. Overall, we found no significant association between MCP-1 -2518A>G polymorphism and asthma susceptibility in any of the genetic model comparisons. After stratified analysis by ethnicity, the results showed that a significant association with asthma risk was found in Caucasians in all the genetic models. However, a protective association was found in Africans under the dominant model. The present meta-analysis suggested that the MCP-1 -2518 A>G polymorphism is a risk factor for asthma in the Caucasian population, nevertheless it has a protective effect in the African population.

目前已发表的关于单核细胞趋化蛋白-1（MCP-1）-2518A>G多态性与哮喘易感性关联的研究结论尚不统一。为此，本研究开展了一项荟萃分析，以评估MCP-1 -2518A>G多态性对哮喘易感性的影响。本研究检索了PubMed、Web of Science、Wanfang以及中国知网（China National Knowledge Infrastructure, CNKI）数据库，以筛选符合纳入标准的研究。采用合并比值比（OR）及对应的95%置信区间（CI）来量化关联强度。通过敏感性分析评估单个研究对合并效应量的影响，并借助漏斗图与Egger检验评估发表偏倚。最终共纳入8项相关研究，包含1562例哮喘患者与1574例对照个体。整体分析结果显示，在所有遗传模型的比较中，未发现MCP-1 -2518A>G多态性与哮喘易感性存在显著关联。按种族进行分层分析后，结果表明高加索人群在所有遗传模型中均呈现出该多态性与哮喘风险的显著关联。但在显性遗传模型下，非洲人群则呈现出保护性关联。本项荟萃分析表明，MCP-1 -2518A>G多态性在高加索人群中是哮喘的风险因素，而在非洲人群中则对哮喘具有保护作用。