Transcriptome analysis of the scleroderma skin tissue treated with BMSC derived exosome in mouse. Transcriptome analysis of the scleroderma skin tissue treated with BMSC derived exosome in mouse

We aim to explore the transcriptome of the dermis of the bleomycin induced murine scleroderma model which were treated with PBS or bone marrow stem cell derived exosome. Overall design: The bleomycin induced murine scleroderma model were treated with BMSC derived exosome or PBS for 7days.

本研究旨在探究经磷酸盐缓冲液（Phosphate Buffered Saline, PBS）或骨髓干细胞（bone marrow stem cell, BMSC）来源外泌体处理的博莱霉素诱导小鼠硬皮病模型的真皮转录组。总体实验设计：对博莱霉素诱导的小鼠硬皮病模型施以BMSC来源外泌体或PBS两种处理，处理时长均为7天。