Immunoregulatory role of the gut microbiota in inflammatory depression

we analyzed gut microbiota composition in stool, inflammation factor and short chain fatty acid (SCFAs) in plasma, inflammatory and permeability marker in intestinal mucosa in inflammatory depression patients.we found the relative abundance of Bacteroides was significantly higher, and Clostridium was lower in inflammatory depression patients. The SCFA-producing species increased with abnormal butanoate metabolism in the inflammatory depression patients.

本研究针对炎症性抑郁症患者的粪便肠道菌群组成、血浆炎症因子与短链脂肪酸（short chain fatty acid, SCFAs），以及肠黏膜炎症标志物及通透性标志物展开分析。研究发现，炎症性抑郁症患者体内拟杆菌属（Bacteroides）的相对丰度显著升高，梭菌属（Clostridium）的相对丰度则显著降低；同时该类患者体内产短链脂肪酸菌群丰度上升，但伴随丁酸代谢异常。