Characterization of SFPQ role in ovarian cancer cell lines

SFPQ is a multifunctional nuclear protein first identified as a splicing factor, that participates in several cellular activities, including RNA transport, apoptosis and DNA repair. Here we report that SFPQ is a key mediator of platinum sensitivity in Epithelial Ovarian Cancer cell lines. GEP experiments were performed in human ovarian cancer cell lines silenced for SFPQ, with Agilent platform. Bioinformatics analyses were performed by Gene Springs

SFPQ是一种多功能核蛋白，最初作为剪接因子被鉴定，参与RNA转运、细胞凋亡及DNA修复等多种细胞生物学过程。本研究发现，SFPQ是上皮性卵巢癌细胞系中铂类药物敏感性的关键介导因子。研究采用安捷伦（Agilent）平台，对经SFPQ基因沉默的人卵巢癌细胞系开展了基因表达谱（Gene Expression Profiling, GEP）实验。生物信息学分析借助Gene Springs工具完成。