Extensive oscillatory gene expression during C. elegans larval development [Ribosome footprinting]. Caenorhabditis elegans

We report the presence of extensive, transcriptionally controlled oscillations in the C. elegans, developmental transcriptome. Furthermore, using ribosome profiling, we show that these oscillating transcripts are actively translated. Overall design: Ribosome-profiling analysis of a timecourse that was collected over C. elegans development

本研究报道了秀丽隐杆线虫（C. elegans）发育转录组中存在广泛的、受转录调控的振荡现象。此外，本研究通过核糖体印迹（ribosome profiling）技术证实，这类振荡表达的转录本可被活跃翻译。实验设计概况：针对秀丽隐杆线虫发育全过程中采集的时间序列样本开展核糖体印迹分析。