Comparison of the clinical features between patients with the wild type and mutations in the preC/C region.

aA mutation was defined through comparisons with the consensus sequence of HBV strains in our cohort and 17 reference strains.
bN.S: Not significant.
cCH: Chronic hepatitis, LC: Liver cirrhosis, HCC: Hepatocellular carcinoma.
dThe number of patients whose ALT levels were greater than the upper limits of normal ALT levels for men (30 IU/L) and women (19 IU/L) [46].

a 突变通过比对本研究队列中的乙型肝炎病毒（Hepatitis B Virus, HBV）毒株与17株参考毒株的共识序列进行定义。
b N.S：无统计学意义（Not significant）。
c CH：慢性肝炎（Chronic hepatitis）、LC：肝硬化（Liver cirrhosis）、HCC：肝细胞癌（Hepatocellular carcinoma）。
d 丙氨酸氨基转移酶（Alanine Aminotransferase, ALT）水平高于男性正常参考上限（30 IU/L）及女性正常参考上限（19 IU/L）[46]的患者例数。