BRD4 inhibitor GNE987 exerts anti-cancer effects by targeting C-Myc and S100A16 in Glioblastoma. BRD4 inhibitor GNE987 exerts anti-cancer effects by targeting C-Myc and S100A16 in Glioblastoma

To investigate the function of GNE987 in the regulation of gene expression, we treated U87 cells with control (DMSO) or GNE987, respectively. We then performed gene expression profiling analysis using data obtained from RNA-seq of control and GNE987 treatment. Overall design: Comparative gene expression profiling analysis of RNA-seq data for U87 cells treated with control (DMSO) or GNE987 for 48h.

为探究GNE987在基因表达调控中的功能，我们分别以对照（二甲基亚砜，DMSO）与GNE987处理U87细胞。随后，我们基于对照组与GNE987处理组的RNA测序（RNA-seq）数据开展基因表达谱分析。实验整体设计：针对经对照（DMSO）或GNE987处理48小时的U87细胞的RNA-seq数据，开展对比性基因表达谱分析。