Exploring how ketamine affects the brain function in people with difficult-to-treat depression - NeuroKet 2.0

*This study is ongoing, date on last data collection expected 20/12/2027. Data will be available to request following publication of the primary outcome paper, for an indefinite time.

This dataset contains de identified clinical, behavioural, neuroimaging, and passive sensing data from an interventional randomised controlled study examining the neural and symptomatic effects of a single subcutaneous ketamine dose in adults with difficult to treat depression. Participants were randomised to receive ketamine (0.75 mg/kg) or saline placebo under medical supervision, with an additional healthy control group undergoing neuroimaging only. Ultra high field 7 Tesla functional MRI was conducted at baseline and 24-48 hours post intervention to assess habenula activity, connectivity, and photosensitivity, alongside clinician rated and self reported measures of depressive symptoms, anxiety, anhedonia, motivation, circadian preference, and quality of life. Objective behavioural and circadian measures were collected using actigraphy and passive mobile sensing before and after intervention. The dataset supports secondary analyses of ketamine's acute neural mechanisms, symptom change, and digitally derived behavioural markers in depression.

本研究目前仍在进行中，末次数据收集预计于2027年12月20日完成。主要结局论文发表后，研究人员可申请获取本数据集，获取权限无时间限制。
本数据集包含去标识化（de-identified）的临床、行为、神经影像及被动传感数据，源自一项干预性随机对照研究，旨在探究单次皮下注射氯胺酮（ketamine）对难治性成年抑郁症患者的神经及症状影响。受试者被随机分配至氯胺酮组（0.75 mg/kg）或生理盐水安慰剂组，研究全程在医学监督下开展；此外还设有仅接受神经影像扫描的健康对照组。
研究分别于基线及干预后24至48小时开展超高场7特斯拉功能磁共振成像（7 Tesla functional MRI）扫描，以评估缰核（habenula）的活动、连接性与光敏感性；同时收集临床医师评定及受试者自评的抑郁症状、焦虑、快感缺失、动机水平、昼夜节律偏好及生活质量相关量表数据。
干预前后，通过腕动计（actigraphy）与被动移动传感技术收集客观行为及昼夜节律相关指标数据。
本数据集可用于氯胺酮急性神经机制、症状变化及抑郁症中数字化行为标志物的二次分析。